| Date | Home | Away | Result |
|---|---|---|---|
| 22/10/22 18:00 | Union Santa Fe | Central Cordoba | 1-4 |
| 22/10/22 20:30 | Defensa y Justicia Florencio Varela | Atletico Tucuman | 3-1 |
| 22/10/22 20:30 | CA San Lorenzo | CA Aldosivi | 3-0 |
| 22/10/22 20:30 | Estudiantes de La Plata | CD Godoy Cruz | 2-0 |
| 22/10/22 23:30 | Argentinos Juniors | CA Velez Sarsfield | 2-0 |
| 23/10/22 16:00 | CA Banfield | CA Sarmiento Junin | 0-0 |
| 23/10/22 18:30 | CA Talleres | Gimnasia y Esgrima La Plata | 2-1 |
| 23/10/22 21:00 | CA Patronato Parana | CA Huracan | 3-2 |
| 23/10/22 21:00 | Racing Club | River Plate | 1-2 |
| 23/10/22 21:00 | Boca Juniors | Independiente | 2-2 |
| 24/10/22 19:30 | Barracas Central | Newell's Old Boys | 1-1 |
| 24/10/22 20:30 | Rosario Central | Club Atlético Colón | 1-1 |
| 25/10/22 00:30 | CA Tigre | Arsenal de Sarandi | 1-4 |
| 26/10/22 00:00 | CA Platense | CA Lanus | 1-1 |