| Date | Home | Away | Result |
|---|---|---|---|
| 08/05/21 17:00 | CD Godoy Cruz | CA Banfield | 0-1 |
| 08/05/21 19:30 | Gimnasia y Esgrima La Plata | CA Velez Sarsfield | 0-5 |
| 08/05/21 19:30 | Atletico Tucuman | Defensa y Justicia Florencio Varela | 5-0 |
| 08/05/21 22:00 | CA Patronato Parana | Boca Juniors | 1-0 |
| 09/05/21 14:00 | Arsenal de Sarandi | Central Cordoba | 1-1 |
| 09/05/21 16:10 | Argentinos Juniors | Estudiantes de La Plata | 2-0 |
| 09/05/21 18:30 | Racing Club | CA San Lorenzo | 2-0 |
| 09/05/21 18:30 | CA Platense | Rosario Central | 4-1 |
| 09/05/21 18:30 | River Plate | CA Aldosivi | 4-1 |
| 09/05/21 22:00 | CA Huracan | Independiente | 1-3 |
| 09/05/21 22:00 | CA Lanus | CA Talleres | 1-0 |
| 09/05/21 22:00 | Club Atlético Colón | Union Santa Fe | 1-1 |
| 10/05/21 01:00 | Newell's Old Boys | CA Sarmiento Junin | 1-1 |