| Date | Home | Away | Result |
|---|---|---|---|
| 10/12/21 22:15 | CA Platense | CA Velez Sarsfield | 3-2 |
| 11/12/21 00:30 | Estudiantes de La Plata | CA Aldosivi | 2-3 |
| 11/12/21 20:00 | Argentinos Juniors | CA Sarmiento Junin | 2-0 |
| 11/12/21 20:00 | Union Santa Fe | Club Atlético Colón | 3-0 |
| 11/12/21 20:00 | Rosario Central | CA Huracan | 1-4 |
| 11/12/21 20:00 | Racing Club | CD Godoy Cruz | 2-1 |
| 11/12/21 20:00 | CA Patronato Parana | Gimnasia y Esgrima La Plata | 0-0 |
| 11/12/21 22:15 | Atletico Tucuman | River Plate | 1-1 |
| 12/12/21 01:00 | Boca Juniors | Central Cordoba | 8-1 |
| 12/12/21 20:00 | CA San Lorenzo | Newell's Old Boys | 3-2 |
| 12/12/21 22:15 | Defensa y Justicia Florencio Varela | CA Lanus | 2-1 |
| 13/12/21 00:30 | CA Talleres | Independiente | 1-2 |
| 13/12/21 23:00 | CA Banfield | Arsenal de Sarandi | 0-0 |