| Date | Home | Away | Result |
|---|---|---|---|
| 23/02/16 19:45 | Middlesbrough FC | Cardiff City | 3-1 |
| 23/02/16 19:45 | Preston North End | Charlton Athletic | 2-1 |
| 23/02/16 19:45 | Birmingham City | Bolton Wanderers | 1-0 |
| 23/02/16 19:45 | Ipswich Town | Hull City A.F.C. | 0-1 |
| 23/02/16 19:45 | Brentford FC | Wolverhampton Wanderers | 3-0 |
| 23/02/16 19:45 | Sheffield Wednesday | Queens Park Rangers | 1-1 |
| 23/02/16 19:45 | Bristol City | Brighton and Hove Albion | 0-4 |
| 23/02/16 19:45 | Burnley FC | Nottingham Forest | 1-0 |
| 23/02/16 19:45 | Milton Keynes Dons FC | Huddersfield Town | 1-1 |
| 23/02/16 19:45 | Leeds United | Fulham FC | 1-1 |
| 23/02/16 20:00 | Reading FC | Rotherham United | 1-0 |
| 24/02/16 19:45 | Derby County | Blackburn Rovers | 1-0 |