| Date | Home | Away | Result |
|---|---|---|---|
| 07/05/22 12:30 | Derby County | Cardiff City | 0-1 |
| 07/05/22 12:30 | Swansea City | Queens Park Rangers | 0-1 |
| 07/05/22 12:30 | Sheffield United | Fulham FC | 4-0 |
| 07/05/22 12:30 | Stoke City | Coventry City | 1-1 |
| 07/05/22 12:30 | West Bromwich Albion | Barnsley FC | 4-0 |
| 07/05/22 12:30 | Birmingham City | Blackburn Rovers | 1-2 |
| 07/05/22 12:30 | AFC Bournemouth | Millwall FC | 1-0 |
| 07/05/22 12:30 | Huddersfield Town | Bristol City | 2-0 |
| 07/05/22 12:30 | Hull City A.F.C. | Nottingham Forest | 1-1 |
| 07/05/22 12:30 | Luton Town | Reading FC | 1-0 |
| 07/05/22 12:30 | Peterborough United | FC Blackpool | 5-0 |
| 07/05/22 12:30 | Preston North End | Middlesbrough FC | 4-1 |