| Date | Home | Away | Result |
|---|---|---|---|
| 02/09/22 20:00 | West Bromwich Albion | Burnley FC | 1-1 |
| 03/09/22 15:00 | Blackburn Rovers | Bristol City | 2-3 |
| 03/09/22 15:00 | Norwich City | Coventry City | 3-0 |
| 03/09/22 15:00 | Swansea City | Queens Park Rangers | 1-0 |
| 03/09/22 15:00 | Rotherham United | Watford FC | 1-1 |
| 03/09/22 15:00 | Millwall FC | Cardiff City | 2-0 |
| 03/09/22 15:00 | Preston North End | Birmingham City | 0-1 |
| 03/09/22 15:00 | Luton Town | Wigan Athletic | 1-2 |
| 04/09/22 12:00 | Reading FC | Stoke City | 2-1 |
| 04/09/22 15:00 | Hull City A.F.C. | Sheffield United | 0-2 |
| 04/09/22 15:00 | Huddersfield Town | FC Blackpool | 0-1 |
| 05/09/22 20:00 | Middlesbrough FC | AFC Sunderland | 1-0 |