| Date | Home | Away | Result |
|---|---|---|---|
| 01/11/22 19:45 | Hull City A.F.C. | Middlesbrough FC | 1-3 |
| 01/11/22 19:45 | Luton Town | Reading FC | 0-0 |
| 01/11/22 19:45 | Coventry City | Blackburn Rovers | 1-0 |
| 01/11/22 19:45 | Preston North End | Swansea City | 1-0 |
| 01/11/22 20:00 | West Bromwich Albion | FC Blackpool | 1-0 |
| 01/11/22 20:00 | Bristol City | Sheffield United | 0-1 |
| 02/11/22 19:45 | Wigan Athletic | Stoke City | 0-1 |
| 02/11/22 19:45 | Cardiff City | Watford FC | 1-2 |
| 02/11/22 19:45 | Birmingham City | Millwall FC | 0-0 |
| 02/11/22 19:45 | Huddersfield Town | AFC Sunderland | 0-2 |
| 02/11/22 19:45 | Norwich City | Queens Park Rangers | 0-0 |
| 02/11/22 19:45 | Burnley FC | Rotherham United | 3-2 |