| Date | Home | Away | Result |
|---|---|---|---|
| 22/10/22 12:30 | FC Blackpool | Preston North End | 4-2 |
| 22/10/22 15:00 | Blackburn Rovers | Birmingham City | 2-1 |
| 22/10/22 15:00 | Rotherham United | Hull City A.F.C. | 2-4 |
| 22/10/22 15:00 | Sheffield United | Norwich City | 2-2 |
| 22/10/22 15:00 | AFC Sunderland | Burnley FC | 2-4 |
| 22/10/22 15:00 | Middlesbrough FC | Huddersfield Town | 0-0 |
| 22/10/22 15:00 | Stoke City | Coventry City | 0-2 |
| 22/10/22 15:00 | Millwall FC | West Bromwich Albion | 2-1 |
| 22/10/22 15:00 | Reading FC | Bristol City | 2-0 |
| 22/10/22 15:00 | Queens Park Rangers | Wigan Athletic | 2-1 |
| 23/10/22 12:00 | Watford FC | Luton Town | 4-0 |
| 23/10/22 12:00 | Swansea City | Cardiff City | 2-0 |