| Date | Home | Away | Result |
|---|---|---|---|
| 04/10/22 19:45 | Luton Town | Huddersfield Town | 3-3 |
| 04/10/22 19:45 | Bristol City | Coventry City | 0-0 |
| 04/10/22 19:45 | Sheffield United | Queens Park Rangers | 0-1 |
| 04/10/22 19:45 | AFC Sunderland | FC Blackpool | 0-0 |
| 04/10/22 20:00 | Cardiff City | Blackburn Rovers | 1-0 |
| 04/10/22 20:00 | Reading FC | Norwich City | 1-1 |
| 05/10/22 19:45 | Hull City A.F.C. | Wigan Athletic | 2-1 |
| 05/10/22 19:45 | Rotherham United | Millwall FC | 1-1 |
| 05/10/22 19:45 | Middlesbrough FC | Birmingham City | 1-0 |
| 05/10/22 19:45 | Burnley FC | Stoke City | 1-1 |
| 05/10/22 19:45 | Watford FC | Swansea City | 1-2 |
| 05/10/22 20:00 | Preston North End | West Bromwich Albion | 1-0 |