| Date | Home | Away | Result |
|---|---|---|---|
| 18/09/21 12:30 | Hull City A.F.C. | Sheffield United | 1-3 |
| 18/09/21 15:00 | Cardiff City | AFC Bournemouth | 0-1 |
| 18/09/21 15:00 | Luton Town | Swansea City | 3-3 |
| 18/09/21 15:00 | Huddersfield Town | Nottingham Forest | 0-2 |
| 18/09/21 15:00 | Middlesbrough FC | FC Blackpool | 1-2 |
| 18/09/21 15:00 | Millwall FC | Coventry City | 1-1 |
| 18/09/21 15:00 | Peterborough United | Birmingham City | 3-0 |
| 18/09/21 15:00 | Preston North End | West Bromwich Albion | 1-1 |
| 18/09/21 15:00 | Queens Park Rangers | Bristol City | 1-2 |
| 18/09/21 15:00 | Barnsley FC | Blackburn Rovers | 0-0 |
| 18/09/21 15:00 | Derby County | Stoke City | 2-1 |
| 18/09/21 15:00 | Fulham FC | Reading FC | 1-2 |