| Date | Home | Away | Result |
|---|---|---|---|
| 14/09/21 19:45 | Blackburn Rovers | Hull City A.F.C. | 2-0 |
| 14/09/21 19:45 | FC Blackpool | Huddersfield Town | 0-3 |
| 14/09/21 19:45 | AFC Bournemouth | Queens Park Rangers | 2-1 |
| 14/09/21 19:45 | Sheffield United | Preston North End | 2-2 |
| 14/09/21 20:00 | Reading FC | Peterborough United | 3-1 |
| 14/09/21 20:00 | West Bromwich Albion | Derby County | 0-0 |
| 15/09/21 19:45 | Coventry City | Cardiff City | 1-0 |
| 15/09/21 19:45 | Swansea City | Millwall FC | 0-0 |
| 15/09/21 19:45 | Birmingham City | Fulham FC | 1-4 |
| 15/09/21 19:45 | Bristol City | Luton Town | 1-1 |
| 15/09/21 19:45 | Nottingham Forest | Middlesbrough FC | 0-2 |
| 15/09/21 19:45 | Stoke City | Barnsley FC | 1-1 |