| Date | Home | Away | Result |
|---|---|---|---|
| 10/09/21 20:00 | Birmingham City | Derby County | 2-0 |
| 11/09/21 15:00 | Swansea City | Hull City A.F.C. | 0-0 |
| 11/09/21 15:00 | Stoke City | Huddersfield Town | 2-1 |
| 11/09/21 15:00 | West Bromwich Albion | Millwall FC | 1-1 |
| 11/09/21 15:00 | Blackburn Rovers | Luton Town | 2-2 |
| 11/09/21 15:00 | FC Blackpool | Fulham FC | 1-0 |
| 11/09/21 15:00 | AFC Bournemouth | Barnsley FC | 3-0 |
| 11/09/21 15:00 | Bristol City | Preston North End | 0-0 |
| 11/09/21 15:00 | Coventry City | Middlesbrough FC | 2-0 |
| 11/09/21 15:00 | Sheffield United | Peterborough United | 6-2 |
| 11/09/21 15:00 | Reading FC | Queens Park Rangers | 3-3 |
| 12/09/21 14:30 | Nottingham Forest | Cardiff City | 1-2 |