| Date | Home | Away | Result |
|---|---|---|---|
| 28/08/21 12:30 | Cardiff City | Bristol City | 1-2 |
| 28/08/21 12:30 | Derby County | Nottingham Forest | 1-1 |
| 28/08/21 15:00 | Preston North End | Swansea City | 3-1 |
| 28/08/21 15:00 | Fulham FC | Stoke City | 3-0 |
| 28/08/21 15:00 | Huddersfield Town | Reading FC | 4-0 |
| 28/08/21 15:00 | Hull City A.F.C. | AFC Bournemouth | 0-0 |
| 28/08/21 15:00 | Luton Town | Sheffield United | 0-0 |
| 28/08/21 15:00 | Middlesbrough FC | Blackburn Rovers | 1-1 |
| 28/08/21 15:00 | Millwall FC | FC Blackpool | 2-1 |
| 28/08/21 15:00 | Barnsley FC | Birmingham City | 1-1 |
| 28/08/21 15:00 | Queens Park Rangers | Coventry City | 2-0 |
| 28/08/21 20:00 | Peterborough United | West Bromwich Albion | 0-1 |