| Date | Home | Away | Result |
|---|---|---|---|
| 18/04/22 12:30 | Middlesbrough FC | Huddersfield Town | 0-2 |
| 18/04/22 15:00 | Cardiff City | Luton Town | 0-1 |
| 18/04/22 15:00 | Reading FC | Swansea City | 4-4 |
| 18/04/22 15:00 | Millwall FC | Hull City A.F.C. | 2-1 |
| 18/04/22 15:00 | Queens Park Rangers | Derby County | 1-0 |
| 18/04/22 15:00 | Barnsley FC | Peterborough United | 0-2 |
| 18/04/22 15:00 | Blackburn Rovers | Stoke City | 0-1 |
| 18/04/22 15:00 | FC Blackpool | Birmingham City | 6-1 |
| 18/04/22 15:00 | Coventry City | AFC Bournemouth | 0-3 |
| 18/04/22 17:30 | Bristol City | Sheffield United | 1-1 |
| 18/04/22 20:00 | Nottingham Forest | West Bromwich Albion | 4-0 |
| 19/04/22 19:45 | Fulham FC | Preston North End | 3-0 |