| Date | Home | Away | Result |
|---|---|---|---|
| 15/04/22 12:30 | Luton Town | Nottingham Forest | 1-0 |
| 15/04/22 15:00 | Hull City A.F.C. | Cardiff City | 2-1 |
| 15/04/22 15:00 | Swansea City | Barnsley FC | 1-1 |
| 15/04/22 15:00 | Birmingham City | Coventry City | 2-4 |
| 15/04/22 15:00 | AFC Bournemouth | Middlesbrough FC | 0-0 |
| 15/04/22 15:00 | Peterborough United | Blackburn Rovers | 2-1 |
| 15/04/22 15:00 | Preston North End | Millwall FC | 1-1 |
| 15/04/22 15:00 | Sheffield United | Reading FC | 1-2 |
| 15/04/22 15:00 | Stoke City | Bristol City | 0-1 |
| 15/04/22 15:00 | West Bromwich Albion | FC Blackpool | 2-1 |
| 15/04/22 17:30 | Huddersfield Town | Queens Park Rangers | 2-2 |
| 15/04/22 20:00 | Derby County | Fulham FC | 2-1 |