| Date | Home | Away | Result |
|---|---|---|---|
| 09/04/22 12:45 | Sheffield United | AFC Bournemouth | 0-0 |
| 09/04/22 15:00 | Reading FC | Cardiff City | 1-2 |
| 09/04/22 15:00 | Swansea City | Derby County | 2-1 |
| 09/04/22 15:00 | Blackburn Rovers | FC Blackpool | 1-1 |
| 09/04/22 15:00 | West Bromwich Albion | Stoke City | 1-3 |
| 09/04/22 15:00 | Bristol City | Peterborough United | 1-1 |
| 09/04/22 15:00 | Middlesbrough FC | Hull City A.F.C. | 0-1 |
| 09/04/22 15:00 | Millwall FC | Barnsley FC | 4-1 |
| 09/04/22 15:00 | Nottingham Forest | Birmingham City | 2-0 |
| 09/04/22 15:00 | Preston North End | Queens Park Rangers | 2-1 |
| 10/04/22 15:00 | Fulham FC | Coventry City | 1-3 |
| 11/04/22 19:45 | Huddersfield Town | Luton Town | 2-0 |