| Date | Home | Away | Result |
|---|---|---|---|
| 20/08/21 19:45 | Bristol City | Swansea City | 0-1 |
| 21/08/21 12:30 | Queens Park Rangers | Barnsley FC | 2-2 |
| 21/08/21 15:00 | Blackburn Rovers | West Bromwich Albion | 1-2 |
| 21/08/21 15:00 | AFC Bournemouth | FC Blackpool | 2-2 |
| 21/08/21 15:00 | Derby County | Middlesbrough FC | 0-0 |
| 21/08/21 15:00 | Fulham FC | Hull City A.F.C. | 2-0 |
| 21/08/21 15:00 | Luton Town | Birmingham City | 0-5 |
| 21/08/21 15:00 | Preston North End | Peterborough United | 1-0 |
| 21/08/21 15:00 | Sheffield United | Huddersfield Town | 1-2 |
| 21/08/21 15:00 | Cardiff City | Millwall FC | 3-1 |
| 21/08/21 15:00 | Coventry City | Reading FC | 2-1 |
| 21/08/21 15:00 | Stoke City | Nottingham Forest | 1-0 |