| Date | Home | Away | Result |
|---|---|---|---|
| 19/03/22 12:30 | Derby County | Coventry City | 1-1 |
| 19/03/22 12:30 | Sheffield United | Barnsley FC | 2-0 |
| 19/03/22 15:00 | Swansea City | Birmingham City | 0-0 |
| 19/03/22 15:00 | Bristol City | West Bromwich Albion | 2-2 |
| 19/03/22 15:00 | Huddersfield Town | AFC Bournemouth | 0-3 |
| 19/03/22 15:00 | Hull City A.F.C. | Luton Town | 1-3 |
| 19/03/22 15:00 | Reading FC | Blackburn Rovers | 1-0 |
| 19/03/22 15:00 | Stoke City | Millwall FC | 2-0 |
| 20/03/22 12:30 | Queens Park Rangers | Peterborough United | 1-3 |
| 05/04/22 19:45 | Preston North End | FC Blackpool | 1-0 |
| 26/04/22 19:45 | Fulham FC | Nottingham Forest | 0-1 |
| 27/04/22 19:45 | Middlesbrough FC | Cardiff City | 2-0 |