| Date | Home | Away | Result |
|---|---|---|---|
| 11/03/22 20:00 | West Bromwich Albion | Huddersfield Town | 2-2 |
| 12/03/22 12:30 | Barnsley FC | Fulham FC | 1-1 |
| 12/03/22 15:00 | FC Blackpool | Swansea City | 1-0 |
| 12/03/22 15:00 | Blackburn Rovers | Bristol City | 0-1 |
| 12/03/22 15:00 | AFC Bournemouth | Derby County | 2-0 |
| 12/03/22 15:00 | Coventry City | Sheffield United | 4-1 |
| 12/03/22 15:00 | Millwall FC | Middlesbrough FC | 0-0 |
| 12/03/22 15:00 | Nottingham Forest | Reading FC | 4-0 |
| 12/03/22 15:00 | Peterborough United | Stoke City | 2-2 |
| 12/03/22 15:00 | Cardiff City | Preston North End | 0-0 |
| 12/03/22 15:00 | Birmingham City | Hull City A.F.C. | 0-0 |
| 13/03/22 12:00 | Luton Town | Queens Park Rangers | 1-2 |