| Date | Home | Away | Result |
|---|---|---|---|
| 04/03/22 19:45 | Sheffield United | Nottingham Forest | 1-1 |
| 04/03/22 19:45 | Huddersfield Town | Peterborough United | 3-0 |
| 05/03/22 12:30 | Fulham FC | Blackburn Rovers | 2-0 |
| 05/03/22 15:00 | Bristol City | Birmingham City | 1-2 |
| 05/03/22 15:00 | Derby County | Barnsley FC | 2-0 |
| 05/03/22 15:00 | Hull City A.F.C. | West Bromwich Albion | 0-2 |
| 05/03/22 15:00 | Middlesbrough FC | Luton Town | 2-1 |
| 05/03/22 15:00 | Preston North End | AFC Bournemouth | 2-1 |
| 05/03/22 15:00 | Reading FC | Millwall FC | 0-1 |
| 05/03/22 15:00 | Queens Park Rangers | Cardiff City | 1-2 |
| 05/03/22 15:00 | Swansea City | Coventry City | 3-1 |
| 05/03/22 15:00 | Stoke City | FC Blackpool | 0-1 |