| Date | Home | Away | Result |
|---|---|---|---|
| 26/02/22 12:30 | Blackburn Rovers | Queens Park Rangers | 1-0 |
| 26/02/22 15:00 | Luton Town | Derby County | 1-0 |
| 26/02/22 15:00 | Millwall FC | Sheffield United | 1-0 |
| 26/02/22 15:00 | Nottingham Forest | Bristol City | 2-0 |
| 26/02/22 15:00 | FC Blackpool | Reading FC | 4-1 |
| 26/02/22 15:00 | AFC Bournemouth | Stoke City | 2-1 |
| 26/02/22 15:00 | Barnsley FC | Middlesbrough FC | 3-2 |
| 26/02/22 15:00 | Cardiff City | Fulham FC | 0-1 |
| 26/02/22 15:00 | Peterborough United | Hull City A.F.C. | 0-3 |
| 26/02/22 15:00 | Coventry City | Preston North End | 1-1 |
| 26/02/22 15:00 | Birmingham City | Huddersfield Town | 0-2 |
| 28/02/22 20:00 | West Bromwich Albion | Swansea City | 0-2 |