| Date | Home | Away | Result |
|---|---|---|---|
| 19/02/22 12:30 | Fulham FC | Huddersfield Town | 1-2 |
| 19/02/22 15:00 | Luton Town | West Bromwich Albion | 2-0 |
| 19/02/22 15:00 | Preston North End | Reading FC | 2-3 |
| 19/02/22 15:00 | Queens Park Rangers | Hull City A.F.C. | 1-1 |
| 19/02/22 15:00 | Cardiff City | FC Blackpool | 1-1 |
| 19/02/22 15:00 | Sheffield United | Swansea City | 4-0 |
| 19/02/22 15:00 | Bristol City | Middlesbrough FC | 2-1 |
| 19/02/22 15:00 | Coventry City | Barnsley FC | 1-0 |
| 19/02/22 15:00 | Derby County | Peterborough United | 1-0 |
| 19/02/22 15:00 | Stoke City | Birmingham City | 2-2 |
| 08/03/22 19:45 | Blackburn Rovers | Millwall FC | 0-0 |
| 03/05/22 19:00 | AFC Bournemouth | Nottingham Forest | 1-0 |