| Date | Home | Away | Result |
|---|---|---|---|
| 12/02/22 12:30 | Huddersfield Town | Sheffield United | 0-0 |
| 12/02/22 15:00 | Middlesbrough FC | Derby County | 4-1 |
| 12/02/22 15:00 | Nottingham Forest | Stoke City | 2-2 |
| 12/02/22 15:00 | Peterborough United | Preston North End | 0-1 |
| 12/02/22 15:00 | Reading FC | Coventry City | 2-3 |
| 12/02/22 15:00 | Millwall FC | Cardiff City | 2-1 |
| 12/02/22 15:00 | Barnsley FC | Queens Park Rangers | 1-0 |
| 12/02/22 15:00 | Birmingham City | Luton Town | 3-0 |
| 12/02/22 15:00 | FC Blackpool | AFC Bournemouth | 1-2 |
| 12/02/22 15:00 | Hull City A.F.C. | Fulham FC | 0-1 |
| 13/02/22 13:00 | Swansea City | Bristol City | 3-1 |
| 14/02/22 20:00 | West Bromwich Albion | Blackburn Rovers | 0-0 |