| Date | Home | Away | Result |
|---|---|---|---|
| 08/02/22 19:45 | Fulham FC | Millwall FC | 3-0 |
| 08/02/22 19:45 | Luton Town | Barnsley FC | 2-1 |
| 08/02/22 19:45 | Stoke City | Swansea City | 3-0 |
| 08/02/22 19:45 | Coventry City | FC Blackpool | 1-1 |
| 08/02/22 19:45 | Derby County | Hull City A.F.C. | 3-1 |
| 09/02/22 19:45 | Blackburn Rovers | Nottingham Forest | 0-2 |
| 09/02/22 19:45 | Cardiff City | Peterborough United | 4-0 |
| 09/02/22 19:45 | Bristol City | Reading FC | 2-1 |
| 09/02/22 19:45 | Preston North End | Huddersfield Town | 0-0 |
| 09/02/22 19:45 | Queens Park Rangers | Middlesbrough FC | 2-2 |
| 09/02/22 19:45 | Sheffield United | West Bromwich Albion | 2-0 |
| 09/02/22 19:45 | AFC Bournemouth | Birmingham City | 3-1 |