| Date | Home | Away | Result |
|---|---|---|---|
| 02/02/22 19:45 | Barnsley FC | Cardiff City | 0-1 |
| 02/02/22 19:45 | Huddersfield Town | Derby County | 2-0 |
| 04/02/22 19:45 | Birmingham City | Sheffield United | 1-2 |
| 05/02/22 15:00 | FC Blackpool | Bristol City | 3-1 |
| 05/02/22 15:00 | Hull City A.F.C. | Preston North End | 0-1 |
| 05/02/22 17:30 | Swansea City | Blackburn Rovers | 1-0 |
| 15/02/22 19:45 | Millwall FC | Queens Park Rangers | 2-0 |
| 05/04/22 19:45 | Peterborough United | Luton Town | 1-1 |
| 05/04/22 20:00 | Reading FC | Stoke City | 2-1 |
| 06/04/22 19:45 | Nottingham Forest | Coventry City | 2-0 |
| 06/04/22 19:45 | Middlesbrough FC | Fulham FC | 0-1 |
| 06/04/22 20:00 | West Bromwich Albion | AFC Bournemouth | 2-0 |