| Date | Home | Away | Result |
|---|---|---|---|
| 17/08/21 19:45 | Barnsley FC | Luton Town | 0-1 |
| 17/08/21 19:45 | FC Blackpool | Coventry City | 0-1 |
| 17/08/21 19:45 | Huddersfield Town | Preston North End | 1-0 |
| 17/08/21 19:45 | Millwall FC | Fulham FC | 1-2 |
| 17/08/21 19:45 | Peterborough United | Cardiff City | 2-2 |
| 17/08/21 19:45 | Swansea City | Stoke City | 1-3 |
| 17/08/21 20:00 | Reading FC | Bristol City | 2-3 |
| 18/08/21 19:45 | Middlesbrough FC | Queens Park Rangers | 2-3 |
| 18/08/21 19:45 | Nottingham Forest | Blackburn Rovers | 1-2 |
| 18/08/21 19:45 | Hull City A.F.C. | Derby County | 0-1 |
| 18/08/21 19:45 | Birmingham City | AFC Bournemouth | 0-2 |
| 18/08/21 20:00 | West Bromwich Albion | Sheffield United | 4-0 |