| Date | Home | Away | Result |
|---|---|---|---|
| 28/01/22 19:45 | Huddersfield Town | Stoke City | 1-1 |
| 29/01/22 15:00 | Barnsley FC | AFC Bournemouth | 0-1 |
| 29/01/22 15:00 | Hull City A.F.C. | Swansea City | 2-0 |
| 29/01/22 15:00 | Fulham FC | FC Blackpool | 1-1 |
| 29/01/22 15:00 | Luton Town | Blackburn Rovers | 0-0 |
| 29/01/22 15:00 | Middlesbrough FC | Coventry City | 1-0 |
| 29/01/22 15:00 | Millwall FC | West Bromwich Albion | 2-0 |
| 29/01/22 15:00 | Preston North End | Bristol City | 2-2 |
| 29/01/22 15:00 | Queens Park Rangers | Reading FC | 4-0 |
| 29/01/22 17:30 | Peterborough United | Sheffield United | 0-2 |
| 30/01/22 13:30 | Derby County | Birmingham City | 2-2 |
| 30/01/22 16:00 | Cardiff City | Nottingham Forest | 2-1 |