| Date | Home | Away | Result |
|---|---|---|---|
| 22/01/22 12:30 | Nottingham Forest | Derby County | 2-1 |
| 22/01/22 12:30 | Bristol City | Cardiff City | 3-2 |
| 22/01/22 15:00 | Birmingham City | Barnsley FC | 2-1 |
| 22/01/22 15:00 | FC Blackpool | Millwall FC | 1-0 |
| 22/01/22 15:00 | AFC Bournemouth | Hull City A.F.C. | 0-1 |
| 22/01/22 15:00 | Coventry City | Queens Park Rangers | 1-2 |
| 22/01/22 15:00 | Reading FC | Huddersfield Town | 3-4 |
| 22/01/22 15:00 | Sheffield United | Luton Town | 2-0 |
| 22/01/22 15:00 | Stoke City | Fulham FC | 2-3 |
| 22/01/22 15:00 | West Bromwich Albion | Peterborough United | 3-0 |
| 22/01/22 15:00 | Swansea City | Preston North End | 1-0 |
| 24/01/22 19:45 | Blackburn Rovers | Middlesbrough FC | 1-0 |