| Date | Home | Away | Result |
|---|---|---|---|
| 01/01/22 15:00 | FC Blackpool | Hull City A.F.C. | 1-0 |
| 02/01/22 13:00 | Bristol City | Millwall FC | 3-2 |
| 02/01/22 14:00 | Birmingham City | Queens Park Rangers | 1-2 |
| 02/01/22 14:00 | Blackburn Rovers | Huddersfield Town | 0-0 |
| 02/01/22 14:00 | West Bromwich Albion | Cardiff City | 1-1 |
| 03/01/22 15:00 | Reading FC | Derby County | 2-2 |
| 03/01/22 15:00 | Stoke City | Preston North End | 1-2 |
| 25/01/22 19:45 | Nottingham Forest | Barnsley FC | 3-0 |
| 08/03/22 19:45 | Coventry City | Luton Town | 0-1 |
| 08/03/22 19:45 | Sheffield United | Middlesbrough FC | 4-1 |
| 08/03/22 19:45 | AFC Bournemouth | Peterborough United | 1-1 |
| 08/03/22 19:45 | Swansea City | Fulham FC | 1-5 |