| Date | Home | Away | Result |
|---|---|---|---|
| 29/12/21 19:45 | Blackburn Rovers | Barnsley FC | 2-1 |
| 29/12/21 19:45 | FC Blackpool | Middlesbrough FC | 1-2 |
| 29/12/21 19:45 | Coventry City | Millwall FC | 0-1 |
| 30/12/21 19:45 | Stoke City | Derby County | 1-2 |
| 30/12/21 19:45 | AFC Bournemouth | Cardiff City | 3-0 |
| 30/12/21 19:45 | Bristol City | Queens Park Rangers | 1-2 |
| 30/12/21 19:45 | Nottingham Forest | Huddersfield Town | 0-1 |
| 11/01/22 20:00 | Reading FC | Fulham FC | 0-7 |
| 25/01/22 19:45 | Birmingham City | Peterborough United | 2-2 |
| 26/01/22 20:00 | West Bromwich Albion | Preston North End | 0-2 |
| 01/02/22 19:45 | Swansea City | Luton Town | 0-1 |
| 15/02/22 19:45 | Sheffield United | Hull City A.F.C. | 0-0 |