| Date | Home | Away | Result |
|---|---|---|---|
| 26/12/21 15:00 | Huddersfield Town | FC Blackpool | 3-2 |
| 26/12/21 15:00 | Middlesbrough FC | Nottingham Forest | 2-0 |
| 27/12/21 15:00 | Derby County | West Bromwich Albion | 1-0 |
| 27/12/21 17:30 | Queens Park Rangers | AFC Bournemouth | 0-1 |
| 18/01/22 19:45 | Preston North End | Sheffield United | 2-2 |
| 18/01/22 19:45 | Fulham FC | Birmingham City | 6-2 |
| 19/01/22 19:45 | Hull City A.F.C. | Blackburn Rovers | 2-0 |
| 25/01/22 19:45 | Luton Town | Bristol City | 2-1 |
| 15/02/22 19:45 | Cardiff City | Coventry City | 2-0 |
| 16/02/22 19:45 | Peterborough United | Reading FC | 0-0 |
| 08/03/22 19:45 | Barnsley FC | Stoke City | 1-1 |
| 05/04/22 19:45 | Millwall FC | Swansea City | 0-1 |