| Date | Home | Away | Result |
|---|---|---|---|
| 03/12/21 19:45 | Fulham FC | AFC Bournemouth | 1-1 |
| 04/12/21 12:30 | Coventry City | West Bromwich Albion | 1-2 |
| 04/12/21 15:00 | Nottingham Forest | Peterborough United | 2-0 |
| 04/12/21 15:00 | Reading FC | Hull City A.F.C. | 1-1 |
| 04/12/21 15:00 | Barnsley FC | Huddersfield Town | 1-1 |
| 04/12/21 15:00 | Blackburn Rovers | Preston North End | 1-0 |
| 04/12/21 15:00 | FC Blackpool | Luton Town | 0-3 |
| 04/12/21 15:00 | Bristol City | Derby County | 1-0 |
| 04/12/21 15:00 | Cardiff City | Sheffield United | 2-3 |
| 04/12/21 15:00 | Middlesbrough FC | Swansea City | 1-0 |
| 04/12/21 15:00 | Millwall FC | Birmingham City | 3-1 |
| 05/12/21 14:30 | Queens Park Rangers | Stoke City | 0-2 |