| Date | Home | Away | Result |
|---|---|---|---|
| 26/11/21 20:00 | West Bromwich Albion | Nottingham Forest | 0-0 |
| 27/11/21 12:30 | Preston North End | Fulham FC | 1-1 |
| 27/11/21 15:00 | Huddersfield Town | Middlesbrough FC | 1-2 |
| 27/11/21 15:00 | Hull City A.F.C. | Millwall FC | 2-1 |
| 27/11/21 15:00 | Peterborough United | Barnsley FC | 0-0 |
| 27/11/21 15:00 | Stoke City | Blackburn Rovers | 0-1 |
| 27/11/21 15:00 | Luton Town | Cardiff City | 1-2 |
| 27/11/21 15:00 | Swansea City | Reading FC | 2-3 |
| 27/11/21 15:00 | Birmingham City | FC Blackpool | 1-0 |
| 27/11/21 15:00 | AFC Bournemouth | Coventry City | 2-2 |
| 28/11/21 12:30 | Sheffield United | Bristol City | 2-0 |
| 29/11/21 19:45 | Derby County | Queens Park Rangers | 1-2 |