| Date | Home | Away | Result |
|---|---|---|---|
| 14/08/21 12:30 | Peterborough United | Derby County | 2-1 |
| 14/08/21 15:00 | Huddersfield Town | Fulham FC | 1-5 |
| 14/08/21 15:00 | Hull City A.F.C. | Queens Park Rangers | 0-3 |
| 14/08/21 15:00 | Middlesbrough FC | Bristol City | 2-1 |
| 14/08/21 15:00 | Millwall FC | Blackburn Rovers | 1-1 |
| 14/08/21 15:00 | Reading FC | Preston North End | 2-1 |
| 14/08/21 15:00 | FC Blackpool | Cardiff City | 0-2 |
| 14/08/21 15:00 | Barnsley FC | Coventry City | 1-0 |
| 14/08/21 15:00 | Birmingham City | Stoke City | 0-0 |
| 14/08/21 15:00 | Nottingham Forest | AFC Bournemouth | 1-2 |
| 14/08/21 15:00 | West Bromwich Albion | Luton Town | 3-2 |
| 14/08/21 20:00 | Swansea City | Sheffield United | 0-0 |