| Date | Home | Away | Result |
|---|---|---|---|
| 23/11/21 19:45 | FC Blackpool | West Bromwich Albion | 0-0 |
| 23/11/21 19:45 | Coventry City | Birmingham City | 0-0 |
| 23/11/21 19:45 | Middlesbrough FC | Preston North End | 1-2 |
| 23/11/21 19:45 | Nottingham Forest | Luton Town | 0-0 |
| 23/11/21 20:00 | Reading FC | Sheffield United | 0-1 |
| 24/11/21 19:45 | Blackburn Rovers | Peterborough United | 4-0 |
| 24/11/21 19:45 | Bristol City | Stoke City | 1-0 |
| 24/11/21 19:45 | Millwall FC | AFC Bournemouth | 1-1 |
| 24/11/21 19:45 | Queens Park Rangers | Huddersfield Town | 1-0 |
| 24/11/21 19:45 | Barnsley FC | Swansea City | 0-2 |
| 24/11/21 19:45 | Cardiff City | Hull City A.F.C. | 0-1 |
| 24/11/21 19:45 | Fulham FC | Derby County | 0-0 |