| Date | Home | Away | Result |
|---|---|---|---|
| 19/11/21 19:45 | Queens Park Rangers | Luton Town | 2-0 |
| 20/11/21 12:30 | Sheffield United | Coventry City | 0-0 |
| 20/11/21 15:00 | Stoke City | Peterborough United | 2-0 |
| 20/11/21 15:00 | Bristol City | Blackburn Rovers | 1-1 |
| 20/11/21 15:00 | Fulham FC | Barnsley FC | 4-1 |
| 20/11/21 15:00 | Huddersfield Town | West Bromwich Albion | 1-0 |
| 20/11/21 15:00 | Preston North End | Cardiff City | 1-2 |
| 20/11/21 15:00 | Swansea City | FC Blackpool | 1-1 |
| 20/11/21 15:00 | Hull City A.F.C. | Birmingham City | 2-0 |
| 20/11/21 15:00 | Middlesbrough FC | Millwall FC | 1-1 |
| 20/11/21 15:00 | Reading FC | Nottingham Forest | 1-1 |
| 21/11/21 12:00 | Derby County | AFC Bournemouth | 3-2 |