| Date | Home | Away | Result |
|---|---|---|---|
| 06/11/21 15:00 | Luton Town | Stoke City | 0-1 |
| 06/11/21 15:00 | Millwall FC | Derby County | 1-1 |
| 06/11/21 15:00 | Nottingham Forest | Preston North End | 3-0 |
| 06/11/21 15:00 | Peterborough United | Fulham FC | 0-1 |
| 06/11/21 15:00 | West Bromwich Albion | Middlesbrough FC | 1-1 |
| 06/11/21 15:00 | AFC Bournemouth | Swansea City | 4-0 |
| 06/11/21 15:00 | Cardiff City | Huddersfield Town | 2-1 |
| 06/11/21 15:00 | Barnsley FC | Hull City A.F.C. | 0-2 |
| 06/11/21 15:00 | Blackburn Rovers | Sheffield United | 3-1 |
| 06/11/21 15:00 | Coventry City | Bristol City | 3-2 |
| 06/11/21 15:30 | Birmingham City | Reading FC | 1-2 |
| 06/11/21 17:30 | FC Blackpool | Queens Park Rangers | 1-1 |