| Date | Home | Away | Result |
|---|---|---|---|
| 02/11/21 19:45 | Peterborough United | Huddersfield Town | 1-1 |
| 02/11/21 19:45 | Coventry City | Swansea City | 1-2 |
| 02/11/21 19:45 | Birmingham City | Bristol City | 3-0 |
| 02/11/21 19:45 | Luton Town | Middlesbrough FC | 3-1 |
| 02/11/21 19:45 | Millwall FC | Reading FC | 1-0 |
| 02/11/21 19:45 | Nottingham Forest | Sheffield United | 1-1 |
| 03/11/21 19:45 | Blackburn Rovers | Fulham FC | 0-7 |
| 03/11/21 19:45 | Barnsley FC | Derby County | 2-1 |
| 03/11/21 19:45 | FC Blackpool | Stoke City | 0-1 |
| 03/11/21 19:45 | Cardiff City | Queens Park Rangers | 0-1 |
| 03/11/21 19:45 | AFC Bournemouth | Preston North End | 1-2 |
| 03/11/21 20:00 | West Bromwich Albion | Hull City A.F.C. | 1-0 |