| Date | Home | Away | Result |
|---|---|---|---|
| 29/10/21 19:45 | Queens Park Rangers | Nottingham Forest | 1-1 |
| 30/10/21 12:30 | Fulham FC | West Bromwich Albion | 3-0 |
| 30/10/21 15:00 | Bristol City | Barnsley FC | 2-1 |
| 30/10/21 15:00 | Derby County | Blackburn Rovers | 1-2 |
| 30/10/21 15:00 | Stoke City | Cardiff City | 3-3 |
| 30/10/21 15:00 | Swansea City | Peterborough United | 3-0 |
| 30/10/21 15:00 | Huddersfield Town | Millwall FC | 1-0 |
| 30/10/21 15:00 | Hull City A.F.C. | Coventry City | 0-1 |
| 30/10/21 15:00 | Middlesbrough FC | Birmingham City | 0-2 |
| 30/10/21 15:00 | Preston North End | Luton Town | 2-0 |
| 30/10/21 15:00 | Sheffield United | FC Blackpool | 0-1 |
| 30/10/21 20:00 | Reading FC | AFC Bournemouth | 0-2 |