| Date | Home | Away | Result |
|---|---|---|---|
| 23/10/21 12:30 | Cardiff City | Middlesbrough FC | 0-2 |
| 23/10/21 15:00 | Coventry City | Derby County | 1-1 |
| 23/10/21 15:00 | Luton Town | Hull City A.F.C. | 1-0 |
| 23/10/21 15:00 | Birmingham City | Swansea City | 2-1 |
| 23/10/21 15:00 | Millwall FC | Stoke City | 2-1 |
| 23/10/21 15:00 | Peterborough United | Queens Park Rangers | 2-1 |
| 23/10/21 15:00 | West Bromwich Albion | Bristol City | 3-0 |
| 23/10/21 15:00 | Blackburn Rovers | Reading FC | 2-0 |
| 23/10/21 15:00 | FC Blackpool | Preston North End | 2-0 |
| 23/10/21 15:00 | AFC Bournemouth | Huddersfield Town | 3-0 |
| 24/10/21 12:30 | Barnsley FC | Sheffield United | 2-3 |
| 24/10/21 15:00 | Nottingham Forest | Fulham FC | 0-4 |