| Date | Home | Away | Result |
|---|---|---|---|
| 19/10/21 19:45 | Bristol City | Nottingham Forest | 1-2 |
| 19/10/21 19:45 | Derby County | Luton Town | 2-2 |
| 19/10/21 19:45 | Queens Park Rangers | Blackburn Rovers | 1-0 |
| 19/10/21 19:45 | Sheffield United | Millwall FC | 1-2 |
| 19/10/21 19:45 | Stoke City | AFC Bournemouth | 0-1 |
| 20/10/21 19:45 | Fulham FC | Cardiff City | 2-0 |
| 20/10/21 19:45 | Swansea City | West Bromwich Albion | 2-1 |
| 20/10/21 19:45 | Huddersfield Town | Birmingham City | 0-0 |
| 20/10/21 19:45 | Hull City A.F.C. | Peterborough United | 1-2 |
| 20/10/21 19:45 | Middlesbrough FC | Barnsley FC | 2-0 |
| 20/10/21 19:45 | Preston North End | Coventry City | 2-1 |
| 20/10/21 20:00 | Reading FC | FC Blackpool | 2-3 |