| Date | Home | Away | Result |
|---|---|---|---|
| 15/10/21 20:00 | West Bromwich Albion | Birmingham City | 1-0 |
| 16/10/21 12:30 | Fulham FC | Queens Park Rangers | 4-1 |
| 16/10/21 15:00 | Blackburn Rovers | Coventry City | 2-2 |
| 16/10/21 15:00 | Bristol City | AFC Bournemouth | 0-2 |
| 16/10/21 15:00 | Huddersfield Town | Hull City A.F.C. | 2-0 |
| 16/10/21 15:00 | Middlesbrough FC | Peterborough United | 2-0 |
| 16/10/21 15:00 | Millwall FC | Luton Town | 0-2 |
| 16/10/21 15:00 | Nottingham Forest | FC Blackpool | 2-1 |
| 16/10/21 15:00 | Preston North End | Derby County | 0-0 |
| 16/10/21 15:00 | Reading FC | Barnsley FC | 1-0 |
| 16/10/21 15:00 | Sheffield United | Stoke City | 2-1 |
| 17/10/21 12:00 | Swansea City | Cardiff City | 3-0 |