| Date | Home | Away | Result |
|---|---|---|---|
| 01/10/21 19:45 | Stoke City | West Bromwich Albion | 1-0 |
| 02/10/21 12:30 | Coventry City | Fulham FC | 4-1 |
| 02/10/21 15:00 | Cardiff City | Reading FC | 0-1 |
| 02/10/21 15:00 | Derby County | Swansea City | 0-0 |
| 02/10/21 15:00 | Hull City A.F.C. | Middlesbrough FC | 2-0 |
| 02/10/21 15:00 | Luton Town | Huddersfield Town | 0-0 |
| 02/10/21 15:00 | Peterborough United | Bristol City | 2-3 |
| 02/10/21 15:00 | Queens Park Rangers | Preston North End | 3-2 |
| 02/10/21 15:00 | Barnsley FC | Millwall FC | 0-1 |
| 02/10/21 15:00 | Birmingham City | Nottingham Forest | 0-3 |
| 02/10/21 15:00 | FC Blackpool | Blackburn Rovers | 2-1 |
| 02/10/21 15:00 | AFC Bournemouth | Sheffield United | 2-1 |