| Date | Home | Away | Result |
|---|---|---|---|
| 28/09/21 19:45 | Cardiff City | West Bromwich Albion | 0-4 |
| 28/09/21 19:45 | Huddersfield Town | Blackburn Rovers | 3-2 |
| 28/09/21 19:45 | Hull City A.F.C. | FC Blackpool | 1-1 |
| 28/09/21 19:45 | Middlesbrough FC | Sheffield United | 2-0 |
| 28/09/21 19:45 | Preston North End | Stoke City | 1-1 |
| 28/09/21 19:45 | Queens Park Rangers | Birmingham City | 2-0 |
| 29/09/21 19:45 | Fulham FC | Swansea City | 3-1 |
| 29/09/21 19:45 | Barnsley FC | Nottingham Forest | 1-3 |
| 29/09/21 19:45 | Derby County | Reading FC | 1-0 |
| 29/09/21 19:45 | Luton Town | Coventry City | 5-0 |
| 29/09/21 19:45 | Millwall FC | Bristol City | 1-0 |
| 29/09/21 19:45 | Peterborough United | AFC Bournemouth | 0-0 |