| Date | Home | Away | Result |
|---|---|---|---|
| 06/08/21 19:45 | AFC Bournemouth | West Bromwich Albion | 2-2 |
| 07/08/21 15:00 | Luton Town | Peterborough United | 3-0 |
| 07/08/21 15:00 | Preston North End | Hull City A.F.C. | 1-4 |
| 07/08/21 15:00 | Queens Park Rangers | Millwall FC | 1-1 |
| 07/08/21 15:00 | Stoke City | Reading FC | 3-2 |
| 07/08/21 15:00 | Bristol City | FC Blackpool | 1-1 |
| 07/08/21 15:00 | Cardiff City | Barnsley FC | 1-1 |
| 07/08/21 15:00 | Derby County | Huddersfield Town | 1-1 |
| 07/08/21 15:00 | Blackburn Rovers | Swansea City | 2-1 |
| 07/08/21 20:00 | Sheffield United | Birmingham City | 0-1 |
| 08/08/21 13:30 | Fulham FC | Middlesbrough FC | 1-1 |
| 08/08/21 16:30 | Coventry City | Nottingham Forest | 2-1 |