| Date | Home | Away | Result |
|---|---|---|---|
| 27/10/20 19:00 | Barnsley FC | Queens Park Rangers | 3-0 |
| 27/10/20 19:45 | Swansea City | Stoke City | 2-0 |
| 27/10/20 19:45 | Wycombe Wanderers | Watford FC | 1-1 |
| 27/10/20 19:45 | Brentford FC | Norwich City | 1-1 |
| 27/10/20 19:45 | Middlesbrough FC | Coventry City | 2-0 |
| 27/10/20 19:45 | Blackburn Rovers | Reading FC | 2-4 |
| 28/10/20 19:00 | Preston North End | Millwall FC | 0-2 |
| 28/10/20 19:45 | Derby County | Cardiff City | 1-1 |
| 28/10/20 19:45 | Rotherham United | Sheffield Wednesday | 3-0 |
| 28/10/20 19:45 | AFC Bournemouth | Bristol City | 1-0 |
| 28/10/20 19:45 | Luton Town | Nottingham Forest | 1-1 |
| 28/10/20 19:45 | Birmingham City | Huddersfield Town | 2-1 |