| Date | Home | Away | Result |
|---|---|---|---|
| 20/10/20 19:45 | Bristol City | Middlesbrough FC | 0-1 |
| 20/10/20 19:45 | Huddersfield Town | Derby County | 1-0 |
| 20/10/20 19:45 | Millwall FC | Luton Town | 2-0 |
| 20/10/20 19:45 | Coventry City | Swansea City | 1-1 |
| 20/10/20 19:45 | Norwich City | Birmingham City | 1-0 |
| 20/10/20 19:45 | Nottingham Forest | Rotherham United | 1-1 |
| 20/10/20 20:00 | Reading FC | Wycombe Wanderers | 1-0 |
| 21/10/20 19:45 | Cardiff City | AFC Bournemouth | 1-1 |
| 21/10/20 19:45 | Queens Park Rangers | Preston North End | 0-2 |
| 21/10/20 19:45 | Sheffield Wednesday | Brentford FC | 1-2 |
| 21/10/20 19:45 | Watford FC | Blackburn Rovers | 3-1 |
| 21/10/20 19:45 | Stoke City | Barnsley FC | 2-2 |