| Date | Home | Away | Result |
|---|---|---|---|
| 09/04/21 19:45 | Watford FC | Reading FC | 2-0 |
| 10/04/21 12:30 | Millwall FC | Swansea City | 0-3 |
| 10/04/21 15:00 | Preston North End | Brentford FC | 0-5 |
| 10/04/21 15:00 | Wycombe Wanderers | Luton Town | 1-3 |
| 10/04/21 15:00 | Bristol City | Nottingham Forest | 0-0 |
| 10/04/21 15:00 | Barnsley FC | Middlesbrough FC | 2-0 |
| 10/04/21 15:00 | AFC Bournemouth | Coventry City | 4-1 |
| 10/04/21 15:00 | Huddersfield Town | Rotherham United | 0-0 |
| 10/04/21 15:00 | Birmingham City | Stoke City | 2-0 |
| 10/04/21 15:00 | Derby County | Norwich City | 0-1 |
| 10/04/21 15:00 | Cardiff City | Blackburn Rovers | 2-2 |
| 10/04/21 15:00 | Queens Park Rangers | Sheffield Wednesday | 4-1 |