| Date | Home | Away | Result |
|---|---|---|---|
| 05/04/21 12:30 | Middlesbrough FC | Watford FC | 1-1 |
| 05/04/21 15:00 | Stoke City | Millwall FC | 1-2 |
| 05/04/21 15:00 | Luton Town | Barnsley FC | 1-2 |
| 05/04/21 15:00 | Nottingham Forest | Queens Park Rangers | 3-1 |
| 05/04/21 15:00 | Blackburn Rovers | AFC Bournemouth | 0-2 |
| 05/04/21 15:00 | Coventry City | Bristol City | 3-1 |
| 05/04/21 15:00 | Swansea City | Preston North End | 0-1 |
| 05/04/21 15:00 | Rotherham United | Wycombe Wanderers | 0-3 |
| 05/04/21 15:00 | Reading FC | Derby County | 3-1 |
| 05/04/21 17:30 | Sheffield Wednesday | Cardiff City | 5-0 |
| 06/04/21 19:00 | Brentford FC | Birmingham City | 0-0 |
| 06/04/21 19:45 | Norwich City | Huddersfield Town | 7-0 |