| Date | Home | Away | Result |
|---|---|---|---|
| 16/03/21 19:00 | Cardiff City | Stoke City | 0-0 |
| 16/03/21 19:00 | Luton Town | Coventry City | 2-0 |
| 16/03/21 19:00 | Middlesbrough FC | Preston North End | 2-0 |
| 16/03/21 19:00 | Rotherham United | Watford FC | 1-4 |
| 16/03/21 19:00 | Derby County | Brentford FC | 2-2 |
| 16/03/21 19:45 | AFC Bournemouth | Swansea City | 3-0 |
| 17/03/21 19:00 | Queens Park Rangers | Millwall FC | 3-2 |
| 17/03/21 19:00 | Wycombe Wanderers | Barnsley FC | 1-3 |
| 17/03/21 19:00 | Nottingham Forest | Norwich City | 0-2 |
| 17/03/21 19:45 | Blackburn Rovers | Bristol City | 0-0 |
| 17/03/21 19:45 | Sheffield Wednesday | Huddersfield Town | 1-1 |
| 17/03/21 19:45 | Birmingham City | Reading FC | 2-1 |